(2S,4S)-1-tert-butyl 2-methyl 4-methoxypyrrolidine-1,2-dicarboxylate synthesis

5synthesis methods

Product Name:(2S,4S)-1-tert-butyl 2-methyl 4-methoxypyrrolidine-1,2-dicarboxylate
CAS Number:215918-38-0
Molecular formula:C12H21NO5
Molecular Weight:259.3

87691-27-8 Synthesis

87691-27-8
222 suppliers
$6.00/250mg

74-88-4
340 suppliers
$15.00/10g

(2S,4S)-1-tert-butyl 2-methyl 4-methoxypyrrolidine-1,2-dicarboxylate

215918-38-0
24 suppliers
$75.00/250MG

Yield:215918-38-0 550 mg

Reaction Conditions:

Stage #1: N-tert-butoxycarbonyl-L-cis-4-hydroxyprolinewith sodium hydride in N,N-dimethyl-formamide; for 0.5 h;Cooling with ice;
Stage #2: methyl iodide in N,N-dimethyl-formamide at 20;

Steps:

A

To an ice cooled mixture of Sodium hydride (228 mg, 5.71 mmol)(prewashed with hexanes) and DMF (10 mL) was added (2S,4S)-l-(tert- butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid (600 mg, 2.59 mmol) as a solid in one portion. The formed slurry was stirred at this temperature for 30 min before addition of iodomethane (0.485 mL, 7.78 mmol) dropwise. The final reaction mixture was stirred at rt overweekend. Poured into water (100 mL), extracted with EtOAc (20 mL, X2). The combined organic layer was washed with water and brine, dried over MgS04, filtered, evaporated in vacuo. The residue was purified by FCC (0% to 50% EtOAc-Hexanes) to afford Cap W-19 Step A (550 mg) as a colorless oil. NMR (500MHz, CD₃OD) δ 4.38 (td, J=8.6, 3.2 Hz, 1H), 3.99 (dt, J=5.1, 2.4 Hz, 1H), 3.81 - 3.68 (m, 3H), 3.64 - 3.53 (m, 1H), 3.50 - 3.40 (m, 1H), 2.45 - 2.21 (m, 2H), 1.55 - 1.40 (m, 9H)

References:

WO2015/5901,2015,A1 Location in patent:Page/Page column 607

24424-99-5 Synthesis