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ChemicalBook CAS DataBase List 4-AMINO-1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID METHYL ESTER

4-AMINO-1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID METHYL ESTER synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: ammonium chloride; ammonium hydroxide / isopropyl alcohol / 20 °C / Inert atmosphere
2: hydrogenchloride; water / 1,4-dioxane / 8 h / Inert atmosphere; Reflux
3: thionyl chloride / 0 - 20 °C / Inert atmosphere

References:

Stotani, Silvia;Lorenz, Christoph;Winkler, Matthias;Medda, Federico;Picazo, Edwige;Ortega Martinez, Raquel;Karawajczyk, Anna;Sanchez-Quesada, Jorge;Giordanetto, Fabrizio [ACS Combinatorial Science,2016,vol. 18,# 6,p. 330 - 336]

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