Remifentanil Hydrochloride synthesis
- Product Name:Remifentanil Hydrochloride
- CAS Number:132539-07-2
- Molecular formula:C20H28N2O5.ClH
- Molecular Weight:412.911
132875-61-7
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132539-07-2
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Yield: 47%
Reaction Conditions:
with hydrogenchloride in methanolPurification / work up;
Steps:
5 Example 5
The HCI salt is obtained by dissolving the free base oil in methanol and adding an HCI solution in methanol. The solution is then cooled to complete crystallisation, and the solid filtered with vacuum to yield 3-[4-methoxycarbonyl-4-[(1-oxopropyl)phenylamino)]-1-piperidine]propanoic acid methyl ester hydrochloride (9.75 g, 47%) as a white solid in a pharmaceutical grade. m.p. 188-189 °C
References:
KERN PHARMA, S.L. EP1867635, 2007, A1 Location in patent:Page/Page column 10-11
41979-39-9
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132539-07-2
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62-53-3
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132539-07-2
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