ChemicalBook CAS DataBase List 2-(CHLOROMETHYL)-5-(4-CHLOROPHENYL)-1,3,4-OXADIAZOLE

2-(CHLOROMETHYL)-5-(4-CHLOROPHENYL)-1,3,4-OXADIAZOLE synthesis

9synthesis methods

Product Name:2-(CHLOROMETHYL)-5-(4-CHLOROPHENYL)-1,3,4-OXADIAZOLE
CAS Number:24068-15-3
Molecular formula:C9H6Cl2N2O
Molecular Weight:229.06

536-40-3 Synthesis

536-40-3
182 suppliers
$5.00/1g

79-11-8
10 suppliers
$27.00/25g

2-(CHLOROMETHYL)-5-(4-CHLOROPHENYL)-1,3,4-OXADIAZOLE

24068-15-3
46 suppliers
$106.04/250mgs:

Yield:24068-15-3 93%

Reaction Conditions:

with trichlorophosphateReflux;

Steps:

6.1.3. General procedure for the synthesis of 5-aryl-2-(chloromethyl)-1,3,4-oxadiazoles (3a-c)

General procedure: A mixture of aryl acid hydrazide (10 mmol), chloroacetic acid (10 mmol) and POCl₃ (7 ml) was heated under reflux for 5-6 h. The excess POCl₃ was removed under reduced pressure and the residue was poured onto crushed ice. The resulting precipitate was filtered, washed with saturated sodium bicarbonate solution and then with water, dried and recrystallized from ethanol to obtain 3.

References:

Padmavathi;Dinneswara Reddy;Nagi Reddy;Mahesh [European Journal of Medicinal Chemistry,2011,vol. 46,# 4,p. 1367 - 1373] Location in patent:experimental part

50677-27-5 Synthesis