![](/CAS/20180703/GIF/244059-08-3.gif)
tert-butyl 3-hydroxy-3-phenylpropyl(methyl)carbamate synthesis
- Product Name:tert-butyl 3-hydroxy-3-phenylpropyl(methyl)carbamate
- CAS Number:244059-08-3
- Molecular formula:C15H23NO3
- Molecular Weight:265.35
![3-Hydroxy-N-methyl-3-phenyl-propylamine](/CAS/GIF/42142-52-9.gif)
42142-52-9
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$11.00/25g
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
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$13.50/25G
![tert-butyl 3-hydroxy-3-phenylpropyl(methyl)carbamate](/CAS/20180703/GIF/244059-08-3.gif)
244059-08-3
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Yield:244059-08-3 100%
Reaction Conditions:
in dichloromethane at 0 - 20; for 2 h;
Steps:
1 Step 1 : tert-Butyl (3-hydroxy-3-phenylpropyl)(methyl)carbamate.
Step 1 : tert-Butyl (3-hydroxy-3-phenylpropyl)(methyl)carbamate. To a solution of 3- (methylamino)-1 -phenylpropan-1 -ol (2 g, 12.1 mmol) in dry DCM (12 ml_), di-tert-butyl dicarbonate (2.91 g, 13.3 mmol) was added at 0 °C and the reaction mixture stirred for 2 h at r.t. Water was added and the aqueous phase was extracted with DCM. The combined organic fractions were washed with sat. NaHCC>3 solution, brine and dried over Mg2SC>4. After filtration the solvent was removed under reduced pressure to afford the title compound (3.2 g, quant, yield) as oil.
References:
WO2019/2173,2019,A1 Location in patent:Page/Page column 58
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7647-01-0
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![3-Hydroxy-N-methyl-3-phenyl-propylamine](/CAS/GIF/42142-52-9.gif)
42142-52-9
363 suppliers
$11.00/25g
![tert-butyl 3-hydroxy-3-phenylpropyl(methyl)carbamate](/CAS/20180703/GIF/244059-08-3.gif)
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![3-CHLORO-1-PHENYL-1-PROPANOL](/CAS/GIF/18776-12-0.gif)
18776-12-0
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![tert-butyl 3-hydroxy-3-phenylpropyl(methyl)carbamate](/CAS/20180703/GIF/244059-08-3.gif)
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![Carbamic acid, N-(3-hydroxy-3-phenylpropyl)-, ethyl ester](/CAS/20210305/GIF/937787-98-9.gif)
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![tert-butyl 3-hydroxy-3-phenylpropyl(methyl)carbamate](/CAS/20180703/GIF/244059-08-3.gif)
244059-08-3
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![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
820 suppliers
$13.50/25G
![3-AMINO-1-PHENYL-PROPAN-1-OL](/CAS/GIF/5053-63-4.gif)
5053-63-4
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$58.00/250mg
![tert-butyl 3-hydroxy-3-phenylpropyl(methyl)carbamate](/CAS/20180703/GIF/244059-08-3.gif)
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