3-Hydroxy-N-methyl-3-phenyl-propylamine synthesis
- Product Name:3-Hydroxy-N-methyl-3-phenyl-propylamine
- CAS Number:42142-52-9
- Molecular formula:C10H15NO
- Molecular Weight:165.24
2538-50-3
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42142-52-9
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Yield:42142-52-9 90%
Reaction Conditions:
with sodium tetrahydroborate in methanol at 20; for 1 h;
Steps:
1
The 2a (0.5mmol) was dissolved in 0.5mL of methanol,At room temperature was slowly added NaBH 4 (2.0mmol),Mixture was stirred at room temperature 1h.Added 2mL saturated NH 4Cl solution.The solvent was removed by distillation under reduced pressure.The residue was added 5mLNaOH (1N),With 5mLCH 2Cl 2 and extracted four times.The organic phase was collected and dried over anhydrous sodium sulfate,And concentrated to give the crude product.The crude product after column chromatography product 2b.Yield: 90%.
References:
YUFEI;YU, FEI CN103992236, 2016, B Location in patent:Paragraph 0051;0054; 0055
18776-12-0
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74-89-5
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42142-52-9
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877-50-9
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5409-62-1
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![1-Propanone, 3-[methyl(phenylmethyl)amino]-1-phenyl-](/CAS/20200401/GIF/21970-65-0.gif)
21970-65-0
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42142-52-9
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