![](/CAS/GIF/82857-39-4.gif)
ent S-(+)-Atomoxetine Hydrochloride synthesis
- Product Name:ent S-(+)-Atomoxetine Hydrochloride
- CAS Number:82857-39-4
- Molecular formula:C17H22ClNO
- Molecular Weight:291.8157
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Yield:-
Steps:
Multi-step reaction with 7 steps
1.1: DCC; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C
2.1: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C
3.1: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
4.1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling
5.1: DEAD; PPh3 / diethyl ether; toluene / 30 h / -10 °C
5.2: 80 percent / diethyl ether; toluene / 2.5 h / -10 °C
6.1: 83 percent / H2O; tetrahydrofuran / 4 h / 60 - 65 °C
7.1: 99 percent / HCl / diethyl ether
References:
Xu, Chengfu;Yuan, Chengye [Tetrahedron,2005,vol. 61,# 8,p. 2169 - 2186]
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95-48-7
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