4-Piperidinecarboxylic acid, 1-phenyl-, ethyl ester synthesis

4synthesis methods

Product Name:4-Piperidinecarboxylic acid, 1-phenyl-, ethyl ester
CAS Number:247022-37-3
Molecular formula:C14H19NO2
Molecular Weight:233.31

1126-09-6 Synthesis

1126-09-6
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108-86-1 Synthesis

108-86-1
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4-Piperidinecarboxylic acid, 1-phenyl-, ethyl ester

247022-37-3
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Yield:247022-37-3 72%

Reaction Conditions:

with 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;sodium t-butanolate;tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ in toluene at 85; for 1.5 h;

Steps:

293 Reference Example 293; ethyl 1-phenylpiperidine-4-carboxylate

To a solution of tetrakisdibenzylidene acetone dipalladium (PD2 (dba) 3) (173 mg, 0.36 mmol), BINAP (560 mg, 0.9 mmol) and sodium tert-butoxide (1.3 g, 13.5 mmol) in toluene (dry, 20 mL) were added bromobenzene (1.6 g, 10 mmol) and ethyl isonipecotinate (1.7 g, 11 mmol) and the mixture was stirred at 85°C for 1.5 hrs. To the reaction solution was added diethyl ether (20 mL) and insoluble materials were celite filtered. The mother liquor was concentrated. The residue was purified by silica gel column chromatography to give the title compound as a slightly yellow oil (1.7 g, yield 72%). : L H NMR (400 MHz, CDC13) 8 PPM : 1.27 (t, J = 7.1 Hz, 3 H), 1.82 - 1. 93 (m, 2 H), 2. 00-2. 05 (m, 2 H), 2.36-2. 47 (TT, J = 10.9, 3.9 Hz, 1 H), 2.78 (TT, J = 12.1, 2.2 Hz, 2 H), 3. 62- 3. 67 (m, 2 H), 4.16 (q, J = 7.1 HZ, 2 H), 6. 82-6. 95 (m, 3 H), 7.23-7. 28 (m, 2 H). LC/MS (ESI) m/z 234 (M+H+).

References:

WO2004/46107,2004,A1 Location in patent:Page 226-227

1126-09-6 Synthesis

1126-09-6
484 suppliers
$15.40/25g

591-50-4 Synthesis