tert-butyl 2-((4R,6R)-6-(2-(2-(4- fluorophenyl)-4-(4- hydroxyphenylcarbamoyl)-5-isopropyl-3- phenyl-1H-pyrrol-1-yl)ethyl)-2,2- dimethyl-1,3-dioxan-4-yl)acetate synthesis

6synthesis methods

Product Name:tert-butyl 2-((4R,6R)-6-(2-(2-(4- fluorophenyl)-4-(4- hydroxyphenylcarbamoyl)-5-isopropyl-3- phenyl-1H-pyrrol-1-yl)ethyl)-2,2- dimethyl-1,3-dioxan-4-yl)acetate
CAS Number:265989-36-4
Molecular formula:C40H47FN2O6
Molecular Weight:670.81

(6-{2-[3-(4-Benzyloxy-phenylcarbamoyl)-5-(4-fluoro-phenyl)-2-isopropyl-4-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester

163217-68-3
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tert-butyl 2-((4R,6R)-6-(2-(2-(4-
fluorophenyl)-4-(4-
hydroxyphenylcarbamoyl)-5-isopropyl-3-
phenyl-1H-pyrrol-1-yl)ethyl)-2,2-
dimethyl-1,3-dioxan-4-yl)acetate

265989-36-4
17 suppliers
$95.00/2mg

Yield:265989-36-4 89.8%

Reaction Conditions:

with palladium on activated charcoal;hydrogen in methanol at 50; under 2585.81 Torr; for 20 h;

Steps:

5 Step 5: Synthesis of tert-butyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-4-((4-hydroxyphenyl)carbamoyl)-5-isopropyl-3-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (9)

_{In MeOH (500 mL) tert-Butyl 2-((4R,6R)-6-(2-(3-((4-(benzyloxy)phenyl)carbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4 phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (4.8 g, 6.31 mmol) add Pd/C (0.8 g, 6.31 mmol, 10% purity) to the mixture, The resulting mixture was stirred at 50° C. under H2 (50 psi) for 20 hours. LCMS showed the main peak of the desired mass, The starting material was consumed. The mixture was filtered through a pad of Celite and the filtrate was concentrated. The residue was purified by silica gel column chromatography (100% EA) to obtain the title compound (3.8 g, 5.66 mmol, 89.80% yield) as a white solid.}

References:

KR102160377,2020,B1 Location in patent:Paragraph 0133; 0190-0194

6373-46-2 Synthesis