(3-Oxo-2,3-dihydro-1H-isoindol-1-yl)acetic acid methyl ester synthesis

7synthesis methods

Product Name:(3-Oxo-2,3-dihydro-1H-isoindol-1-yl)acetic acid methyl ester
CAS Number:28488-99-5
Molecular formula:C11H11NO3
Molecular Weight:205.21

67-56-1 Synthesis

67-56-1
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3849-22-7 Synthesis

3849-22-7
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$45.00/10mg

(3-Oxo-2,3-dihydro-1H-isoindol-1-yl)acetic acid methyl ester

28488-99-5
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Yield:28488-99-5 98%

Reaction Conditions:

with sulfuric acid at 20; for 16.0833 h;

Steps:

6.A

Example 6 6-{2-[2-(4-Fluoro-benzyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-acetylamino}-nicotinic acid A. (3-Oxo-2,3-dihydro-1H-isoindol-1-yl)-acetic acid methyl ester; To a solution of (3-oxo-2,3-dihydro-1H-isoindol-1-yl)-acetic acid (2.0 g, 10.4 mmol) in 100 mL methanol was added 2 mL conc. H₂SO₄over 5 min. The mixture was stirred at room temperature for 16 h. Solvent was evaporated, the crude oil was dissolved in 200 mL EtOAc, then washed with 50 mL sat'd NaHCO₃and 2×50 mL water. The organic phase was dried (Na₂SO₄), filtered, and solvent was evaporated. The title compound was isolated as a yellow oil (2.1 g, 98%).

References:

US2007/99930,2007,A1 Location in patent:Page/Page column 31

201230-82-2 Synthesis