5-(4-BROMO-PHENOXYMETHYL)-[1,3,4]THIADIAZOL-2-YLAMINE synthesis
- Product Name:5-(4-BROMO-PHENOXYMETHYL)-[1,3,4]THIADIAZOL-2-YLAMINE
- CAS Number:299441-95-5
- Molecular formula:C9H8BrN3OS
- Molecular Weight:286.15
Yield:-
Reaction Conditions:
Stage #1: (4-bromophenoxy)acetic acid;thiosemicarbazidewith trichlorophosphate at 75; for 0.5 h;
Stage #2: in water; for 4 h;Reflux;
Steps:
General procedure for the preparation of 2-((phenoxy orsubstituted phenoxy)methyl/ethyl)-1,3,4-thiadiazol-5-amines (4a-qand 5a-q)
General procedure: A mixture of benzoic acid (50 mmol), N-aminothiourea(50 mmol) and POCl3 (13 mL) was heated at 75 C for 0.5 h. Themixture was cooled to which water (10 mL) was added and thereaction mixture was refluxed for 4 h. The mixture was cooled and pH was adjusted to 8.0 by adding 50% sodium hydroxide solution.The separated solid was filtered and recrystallized from ethanolto give desired compounds.
References:
Joshi, Shrinivas D.;More, Uttam A.;Koli, Deepshikha;Kulkarni, Manoj S.;Nadagouda, Mallikarjuna N.;Aminabhavi, Tejraj M. [Bioorganic Chemistry,2015,vol. 59,p. 151 - 167]
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