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2H-1,4-Benzoxazin-7-amine, 3,4-dihydro-4-methyl- synthesis
- Product Name:2H-1,4-Benzoxazin-7-amine, 3,4-dihydro-4-methyl-
- CAS Number:220844-82-6
- Molecular formula:C9H12N2O
- Molecular Weight:164.2
![3,4-dihydro-4-methyl-7-nitro-2H-1,4-benzoxazine](/CAS/20180601/GIF/120711-93-5.gif)
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Yield:220844-82-6 88%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in ethyl acetate at 25; for 2 h;
Steps:
30
A solution of 30-1 (0.530 g, 2.73 mmol) in ethyl acetate (40 mL) was degassed with nitrogen three times then Pd/C (0.053 g, 10% purity on charcoal, wet) was added. The reaction mixture was degassed and purged with hydrogen three times. The mixture was stirred at 25°C for 2 hours under a hydrogen atmosphere (15 psi) then diluted with ethyl acetate (100 mL), filtered, and the filtrate was concentrated under reduced pressure to afford 4-methyl-3, 4-dihydro-2H -benzo[b][1,4]oxazin-7-amine (30-2) (0.430 g, 88.0% yield) as a black brown oil.
References:
WO2022/150574,2022,A1 Location in patent:Page/Page column 181
![7-AMINO-4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE](/CAS/GIF/141068-81-7.gif)
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![OTAVA-BB 1217676](/CAS/GIF/120711-81-1.gif)
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$35.00/100mg
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![7-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE](/CAS/GIF/81721-86-0.gif)
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$16.00/500mg
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$45.95/1gm:
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