(2R)-2-AMINOBUTANE-1,4-DIOL synthesis
- Product Name:(2R)-2-AMINOBUTANE-1,4-DIOL
- CAS Number:80572-06-1
- Molecular formula:C4H11NO2
- Molecular Weight:105.14
672309-94-3
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Yield:80572-06-1 91%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in ethanol; under 760.051 Torr; for 1.5 h;
Steps:
67A (2R)-2-Aminobutan-1,4-diol
Example 67A
(2R)-2-Aminobutan-1,4-diol
500 mg of (R)-2-Cbz-aminobutan-1,4-diol were dissolved in 250 ml of ethanol, a spatula tip of Pd/C (10%) was added and the mixture was hydrogenated with hydrogen at atmospheric pressure for 90 minutes.
The reaction mixture was filtered through kieselguhr, the filter cake was washed with ethanol and the filtrate was concentrated.
This gave 199 mg (91% of theory) of the target compound which was reacted further without further purification.
1H NMR (400 MHz, DMSO-d6): δ=1.22-1.32 (m, 1H), 1.46-1.55 (m, 1H), 2.70-2.76 (m, 1H), 3.12 (dd, 1H), 3.30 (dd, 1H), 3.49 (t, 2H).
References:
US2014/128386,2014,A1 Location in patent:Paragraph 1247; 1248; 1249
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80572-06-1
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