![](/CAS/20200119/GIF/53708-63-7.gif)
(2S)-2-amino-3-(1H-indol-3-yl)-N-methylpropanamide synthesis
- Product Name:(2S)-2-amino-3-(1H-indol-3-yl)-N-methylpropanamide
- CAS Number:53708-63-7
- Molecular formula:C12H15N3O
- Molecular Weight:217.27
Yield:53708-63-7 130 mg
Reaction Conditions:
in ethanol at 40; for 48 h;Inert atmosphere;
Steps:
1 (S)-2-amino-3-(lH-indol-3-yl)-N-methylpropanamide
A solution of (S)-methyl 2-amino-3-(lH-indol-3-yl)propanoate (254 mg, 1.0 mmol) and methylamine (5 niL, 10 mmol) in ethanol (5 mL) was heated at 40 °C for 48 hours. The mixture was concentrated in vacuo to give (S)-2-amino-3-(lH-indol-3-yl)-N-methylpropanamide (130 mg) as a yellow solid. MS (ESI) m/z 218.1 [M + H]+
References:
WO2019/28362,2019,A1 Location in patent:Paragraph 00319; 00320; 00439; 00440
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