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ChemicalBook CAS DataBase List (2S,4R)-BOC-4-PHENYL-PYRROLIDINE-2-CARBOXYLIC ACID

(2S,4R)-BOC-4-PHENYL-PYRROLIDINE-2-CARBOXYLIC ACID synthesis

10synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; 1,4-dioxane / 0.33 h / 80 °C
2: hydrogenchloride / 1,4-dioxane / 0.5 h
3: hydrogen; palladium 10% on activated carbon / ethanol

References:

Kl?ck, Cornelius;Herrera, Zachary;Albertelli, Megan;Khosla, Chaitan [Journal of Medicinal Chemistry,2014,vol. 57,# 21,p. 9042 - 9064]

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