3-(1,3-Dioxolan-2-yl)benzonitrile, 97% synthesis

8synthesis methods

Product Name:3-(1,3-Dioxolan-2-yl)benzonitrile, 97%
CAS Number:153329-04-5
Molecular formula:C10H9NO2
Molecular Weight:175.18

24964-64-5 Synthesis

24964-64-5
319 suppliers
$9.00/1g

153329-04-5
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$181.00/2g

Yield:153329-04-5 100%

Reaction Conditions:

with p-toluenesulfonic acid monohydrate in ethylene glycol;toluene;

Steps:

R.8 Reference Example 8

Reference Example 8 A mixture of 3-cyanobenzaldehyde (9.81 g), ethylene glycol (9.31 g), p-toluenesulfonic acid monohydrate (0.07 g) and toluene (200 ml) was heated under reflux for 15 hrs., while removing generated water with a Dean-Stark trap. After cooling, the reaction mixture was concentrated, and the residue was diluted with ethyl acetate. This solution was washed with saturated aqueous sodium hydrogen carbonate solution and saturated brine; dried over anhydrous magnesium sulfate, and concentrated to give 3-(1,3-dioxolan-2-yl)benzonitrile (13.1 g, yield 100%) as a colorless oil. NMR (CDCl₃) δ: 4.01-4.17 (4H, m), 5.83 (1H, s), 4.50 (1H, t, J = 7.6 Hz), 7.63-7.74 (2H, m), 7.80 (1H, t, J = 1.6 Hz).

References:

EP1405636,2004,A1

24964-64-5 Synthesis

24964-64-5
319 suppliers
$9.00/1g

107-21-1 Synthesis