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ChemicalBook CAS DataBase List 3,3,3-Trifluoro-2,2-dimethylpropionic acid
889940-13-0

3,3,3-Trifluoro-2,2-dimethylpropionic acid synthesis

2synthesis methods
Prepare a dry, clean 1L four-necked flask. 18g of 3,3,3-trifluoro-2,2-dimethylpropanenitrile was added to it, and 500 ml of a 5 mol/L sodium hydroxide aqueous solution was placed in the flask; stir well; the mixture was heated to a temperature of 90-100 ° C and refluxed overnight. The reaction was terminated until 3,3,3-trifluoro-2,2-dimethylpropanenitrile was completely reacted. Concentrated hydrochloric acid was used to adjust the pH to 1. Continue stirring for 30 minutes, Extracted with 50*3ml of dichloromethane; the organic layers were combined and concentrated to give a white solid (3,3,3-Trifluoro-2,2-dimethylpropionic acid). The yield was 84.3% (GC 98%).
3,3,3-Trifluoro-2,2-dimethylpropionic acid
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Yield:889940-13-0 84.3%

Reaction Conditions:

with sodium hydroxide in water at 90 - 100;

Steps:

c Step c, to obtain the target product:
Prepare a dry, clean 1L four-necked flask. 18g of intermediate 2 was added to it, 500 ml of a 5 mol/L sodium hydroxide aqueous solution was placed in the flask, Stir well, The mixture was heated to a temperature of 90-100 ° C and refluxed overnight. The reaction was terminated until the intermediate 2 was completely reacted. Concentrated hydrochloric acid was used to adjust the pH to 1. Continue stirring for 30 minutes, Extracted with 50*3ml of dichloromethane, The organic layers were combined and concentrated to give a white solid. The yield was 84.3% (GC 98%).

References:

Haimen Ruiyi Pharmaceutical Technology Co., Ltd.;Xue Song CN109180459, 2019, A Location in patent:Paragraph 0012

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