3-(TRIFLUOROMETHYL)PYRROLIDINE-3-CARBOXYLICACID synthesis
- Product Name:3-(TRIFLUOROMETHYL)PYRROLIDINE-3-CARBOXYLICACID
- CAS Number:916423-57-9
- Molecular formula:C6H8F3NO2
- Molecular Weight:183.13
67-56-1
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Yield:-
Reaction Conditions:
with hydrogenchloride at 20; for 12 h;Cooling with ice;
Steps:
16
To an ice-cold solution of 3-(trifluoromethyl)pyrrolidine-3-carboxylic acid (0.25 g, 1.36 mmol) in MeOH (5.0 mL) was purged dry-HCl (gas) for 10 minutes. The mixture was stirred at rt for 12 h. After reaction completion (by TLC), solvent was evaporated to obtain a brownish solid material (0.32 g) that was carried forward to the next step without purification. MS: 198.15 [M+H]+.
References:
US2012/88750,2012,A1 Location in patent:Page/Page column 37