3-(4-BENZHYDRYL-1-PIPERAZINYL)-1-PROPANAMINE synthesis
- Product Name:3-(4-BENZHYDRYL-1-PIPERAZINYL)-1-PROPANAMINE
- CAS Number:50971-75-0
- Molecular formula:C20H27N3
- Molecular Weight:309.45
93358-79-3
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50971-75-0
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Yield:50971-75-0 67%
Reaction Conditions:
with hydrazine hydrate in ethanol at 80; for 5 h;
Steps:
11
Weigh accurately obtained above was dissolved in 40mLEtOH S38 740mg 1.69mmol about, and after stirring and dissolving 0.5ml of hydrazine hydrate was added dropwise thereto, placed in 80 ° C oil bath for 5h, TLC detection, after completion of the reaction, cooling , the reaction system was filtered, residue discarded, the filtrate was collected, the filtrate was concentrated on silica gel column chromatography chromatography using elution system containing 1% triethylamine, eluent petroleum ether and ethyl acetate in a volume ratio of : 1 gradient elution was carried out to give 350mg of compound S39 , yield 67.0%
References:
CN103524413,2016,B Location in patent:Paragraph 0154; 0155; 0156; 0160
841-77-0
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50971-75-0
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753436-14-5
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50971-75-0
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776-74-9
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50971-75-0
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75591-22-9
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50971-75-0
5 suppliers
$180.00/1g