3,4-DIAMINOTHIOPHENE DIHYDROCHLORIDE synthesis
- Product Name:3,4-DIAMINOTHIOPHENE DIHYDROCHLORIDE
- CAS Number:90069-81-1
- Molecular formula:C4H7ClN2S
- Molecular Weight:150.62
52431-30-8
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90069-81-1
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Yield: 90%
Reaction Conditions:
with hydrogenchloride;tin in water at 0;
Steps:
1
To the resulting 2,5-dibromo-3,4-dinitrothiophene was added 12 N concentrated hydrochloric acid at a rate of 6.05 ml/mmol.
While the temperature of the resulting solution was kept at 0° C. with an ice bath, tin in an amount of 7.1 equivalents to 2,5-dibromo-3,4-dinitrothiophene was added slowly, followed by stirring for additional 2 hours. Then, the formed solid was collected by filtration and the solid was washed with diethyl ether, so that 3,4-diaminothiophene dihydrochloride was obtained. The yield based on 2,5-dibromo-3,4-dinitrothiophene was 90%. The result of the 1H-NMR measurement of 3,4-diaminothiophene dihydrochloride is shown below. 1H-NMR (500 MHz, DMSO, TMS) δ: 6.95 (2H, s)
References:
Kuraray Co., Ltd.;Kondou, Yoshirou;Nakano, Kirihiro;Otake, Tomiaki US8519150, 2013, B2 Location in patent:Page/Page column 33
19985-45-6
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90069-81-1
126 suppliers
$18.00/100mg