ChemicalBook CAS DataBase List 3,4-Dichlorobenzenebutanoic acid

3,4-Dichlorobenzenebutanoic acid synthesis

9synthesis methods

Product Name:3,4-Dichlorobenzenebutanoic acid
CAS Number:25157-66-8
Molecular formula:C10H10Cl2O2
Molecular Weight:233.09

39960-06-0
5 suppliers
inquiry

25157-66-8
8 suppliers
inquiry

Yield:25157-66-8 100%

Reaction Conditions:

with water;sodium hydroxide in ethanol; for 3 h;Reflux;

Steps:

Intermediate 17. 4-(3 ,4-dichlorophenyl)butanoic acid

Intermediate 17 [00185] Intermediate 17B (900 mg, 4.20 mmol) was dissolved in ethanol (10 mL) and treated with aqueous sodium hydroxide (50% in water, 10 mL). The reaction mixture was heated at reflux for 3 h. After allowing to cool to rt, the mixture was concentrated in vacuo and the crude product dissolved in ethyl acetate and washed with water twice. The combined aqueous layers were acidified to pH -2.0 with concentrated hydrochloric acid. The product precipitated out as a white solid, which was extracted with ethyl acetate twice. The combined organic layers were washed with brine twice, dried over a₂S0₄, filtered and concentrated to afford Intermediate 17 (1.00 g, 4.20 mmol, 100%) as a white solid. HPLC/MS (Method L) RT = 1.97 min, [M+l]⁺ = 233.1.

References:

WO2013/49096,2013,A1 Location in patent:Paragraph 00185

50597-19-8 Synthesis