ChemicalBook CAS DataBase List 3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-AMINE

3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-AMINE synthesis

7synthesis methods

Product Name:3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-AMINE
CAS Number:26011-57-4
Molecular formula:C8H10N2O
Molecular Weight:150.18

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Yield:26011-57-4 99%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in methanol; for 6 h;Parr hydrogenator;

Steps:

3 3,4-Dihydro-2H-benzo[1,4]oxazin-6-ylamine

A solution of 6-nitro-3,4-dihydro-2H-benzo[1,4]oxazine (1.8 g, 10.0 mmol) in methanol (150 mL) was hydrogenated on a Parr hydrogenator for 6 hours with 10% palladium on carbon (1.06 g) as a catalyst. The reaction mixture was filtered through Celite to remove the catalyst and the Celite rinsed with methanol. The filtrate was evaporated under vacuum to yield 3,4-dihydro-2H-benzo[1,4]oxazin-6-yl amine as a solid product. Yield: 1.48 g, 99%

References:

US2004/14743,2004,A1 Location in patent:Page/Page column 12

89976-75-0 Synthesis