ChemicalBook CAS DataBase List 6-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE

6-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE synthesis

8synthesis methods

Product Name:6-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE
CAS Number:89976-75-0
Molecular formula:C8H8N2O2
Molecular Weight:164.16

598-42-5 Synthesis

598-42-5
84 suppliers
$61.00/1g

95-76-1 Synthesis

95-76-1
370 suppliers
$10.00/5g

89976-75-0
84 suppliers
$19.00/100mg

Yield: 98.1%

Reaction Conditions:

with copper acetylacetonate;sodium hydroxide;N,N`-dimethylethylenediamine in dichloromethane;N,N-dimethyl-formamide at 50; for 5 h;Reagent/catalyst;

Steps:

1 Example 1: Preparation of 6-amino-1,4-benzoxazin-3-(4H)-one
Add the appropriate amount of DMF and dichloromethane mixed solvent (30ml) to the reactor.3,4-Dichloroaniline (10 mmol) was added with stirring.Hydroxyacetamide (10 mmol),Copper acetylacetonate catalyst (0.5 mmol),N, N'- dimethylethylenediamine (0.5mmol),NaOH (1 mmol),The reaction is then heated to 50°C for reaction.Reaction 5 hours,TLC detection reaction knot After being bundled, the reaction mixture is poured into saturated saline, stirred rapidly, a large amount of solids precipitate, and filtered and dried to obtain white solid. Body, yield: 98.1%.

References:

Yang Wenlang CN107652249, 2018, A Location in patent:Paragraph 0025-0027; 0037-0046

81721-87-1 Synthesis