3-(4-fluorophenyl)pyrrolidin-1-ium-3-ol chloride synthesis

Yield:-

Reaction Conditions:

with hydrogenchloride in ethyl acetate; for 0.25 h;

Steps:

217

tert-butyl 3-(4-fluorophenyl)-3-hydroxypyrrolidine-1-carboxylate (0.11 g, 0.39 mmol) was dissolved in EtOAc (11 mL) and HCl (g) was bubbled through the solution in a gentle stream for 15 min. Filtration afforded the title compound, This material was used in the next step without further purification. MS (EI) 182 (M+1).

References:

US2008/21022,2008,A1 Location in patent:Page/Page column 96