3,4-(METHYLENEDIOXY)PHENYL-(2-PYRIDYL)METHANOL synthesis
1synthesis methods
- Product Name:3,4-(METHYLENEDIOXY)PHENYL-(2-PYRIDYL)METHANOL
- CAS Number:109218-96-4
- Molecular formula:C13H11NO3
- Molecular Weight:229.23
Yield:109218-96-4 75%
Reaction Conditions:
Stage #1: 2-bromo-pyridinewith isopropylmagnesium chloride in tetrahydrofuran at 20; for 2 h;Inert atmosphere;
Stage #2: piperonalwith water in tetrahydrofuran at 20; for 2 h;Inert atmosphere;
References:
Park, Boyoung Y.;Montgomery, T. Patrick;Garza, Victoria J.;Krische, Michael J. [Journal of the American Chemical Society,2013,vol. 135,# 44,p. 16320 - 16323] Location in patent:supporting information