3-(4-PHENYLPIPERIDIN-2-YL)CYCLOHEXANONE HCL synthesis

1synthesis methods

Product Name:3-(4-PHENYLPIPERIDIN-2-YL)CYCLOHEXANONE HCL
CAS Number:1241505-12-3
Molecular formula:C17H24ClNO
Molecular Weight:293.84

1241505-11-2 Synthesis

TERT-BUTYL 2-(3-OXOCYCLOHEXYL)-4-PHENYLPIPERIDINE-1-CARBOXYLATE

1241505-11-2
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3-(4-PHENYLPIPERIDIN-2-YL)CYCLOHEXANONE HCL

1241505-12-3
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Yield:1241505-12-3 100%

Reaction Conditions:

with hydrogenchloride in methanol; for 2 h;

Steps:

II.2

To a solution of 3 (6.27 g, 17.6mmol) in MeOH (20 mL) was added HCI/MeOH (2 M, 40 mL). After 2 hours, the reaction mixture was concentrated to give 5.1 g of compound 4 as HCl salt in 100 % yields.

References:

WO2010/94242,2010,A1 Location in patent:Preparation II.2