3-((4-(TrifluoroMethyl)phenyl)aMino)benzoic acid synthesis
- Product Name:3-((4-(TrifluoroMethyl)phenyl)aMino)benzoic acid
- CAS Number:1284180-11-5
- Molecular formula:C14H10F3NO2
- Molecular Weight:281.23
![3-[N-(4-trifluoromethylphenyl)amino]benzoic acid methyl ester](/CAS/20211123/GIF/1284180-25-1.gif)
1284180-25-1
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1284180-11-5
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Yield:1284180-11-5 90%
Reaction Conditions:
with water;potassium hydroxide in ethanol at 100;Inert atmosphere;
Steps:
General Procedure B
To a solution of the methyl ester (1 equiv) in EtOH (0.2 M) was added KOH (2 equiv per ester) in water (0.2 M) at room temperature. The reaction mixture was allowed to stir at 100 °C for 1-6 h. Once the reaction appeared complete by TLC analysis, EtOH was evaporated from the reaction mixture, the resultant solution was cooled to 0 °C and acidified to pH 2 w 2M aq HCl. The resultant precipitated product was collected by vacuum filtration and washed with water.
References:
Adeniji, Adegoke O.;Twenter, Barry M.;Byrns, Michael C.;Jin, Yi;Winkler, Jeffrey D.;Penning, Trevor M. [Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,# 5,p. 1464 - 1468] Location in patent:supporting information; experimental part
