ChemicalBook CAS DataBase List Methyl 3-bromobenzoate

Methyl 3-bromobenzoate synthesis

11synthesis methods

Product Name:Methyl 3-bromobenzoate
CAS Number:618-89-3
Molecular formula:C8H7BrO2
Molecular Weight:215.04

585-76-2 Synthesis

585-76-2
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$6.00/5g

618-89-3
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$28.00/5g

Yield:618-89-3 85%

Reaction Conditions:

with sulfuric acid in methanol;dichloromethane;ethyl acetate

Steps:

2.A Methyl 3-(2-α-L-fucopyranosyloxy)phenyl)benzoate
Part A: 3-Bromobenzoic acid (1.1 g, 5.47 mmol) was dissolved in methanol (20 ml) in a 50 ml flask. Concentrated sulfuric acid (2 drops) was added and the mixture was refluxed under nitrogen for ten hours then concentrated under reduced pressure. The residue was mixed with dichloromethane (20 ml) and saturated sodium bicarbonate solution (10 ml). The organic material was separated, dried (MgSO₄) and concentrated under reduced pressure. The residue was flushed through silica gel with hexane/ethyl acetate (3:1), and concentrated which provided methyl 3-bromobenzoate (1.0 g, 85%).

References:

Texas Biotechnology Corporation US5622937, 1997, A

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93-58-3 Synthesis