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ChemicalBook CAS DataBase List Methyl 3-bromobenzoate
618-89-3

Methyl 3-bromobenzoate synthesis

11synthesis methods
-

Yield:618-89-3 85%

Reaction Conditions:

with sulfuric acid in methanol;dichloromethane;ethyl acetate

Steps:

2.A Methyl 3-(2-α-L-fucopyranosyloxy)phenyl)benzoate
Part A: 3-Bromobenzoic acid (1.1 g, 5.47 mmol) was dissolved in methanol (20 ml) in a 50 ml flask. Concentrated sulfuric acid (2 drops) was added and the mixture was refluxed under nitrogen for ten hours then concentrated under reduced pressure. The residue was mixed with dichloromethane (20 ml) and saturated sodium bicarbonate solution (10 ml). The organic material was separated, dried (MgSO4) and concentrated under reduced pressure. The residue was flushed through silica gel with hexane/ethyl acetate (3:1), and concentrated which provided methyl 3-bromobenzoate (1.0 g, 85%).

References:

Texas Biotechnology Corporation US5622937, 1997, A

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