![](/CAS/GIF/86604-78-6.gif)
3,5-Dimethyl-4-methoxy-2-pyridinemethanol synthesis
- Product Name:3,5-Dimethyl-4-methoxy-2-pyridinemethanol
- CAS Number:86604-78-6
- Molecular formula:C9H13NO2
- Molecular Weight:167.21
![2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride](/CAS/GIF/86604-75-3.gif)
86604-75-3
565 suppliers
$10.00/1g
![3,5-Dimethyl-4-methoxy-2-pyridinemethanol](/CAS/GIF/86604-78-6.gif)
86604-78-6
294 suppliers
$7.00/5g
Yield:86604-78-6 83%
Reaction Conditions:
with potassium iodide;sodium hydroxide in methanol;water for 4 h;Reflux;Reagent/catalyst;
Steps:
1.b b. Preparation of 2-hydroxymethyl-3,5-dimethyl-4-methoxypyridine (V)
Take 80 g of 2- (chloromethyl) -4-methoxy-3,5-dimethylpyridine hydrochloride,Add 300 mL of methanol,150 mL water,5.4 g Potassium iodide,40.4 g sodium hydroxide,Stirring heated to reflux, the reaction 4 h.Remove the methanol by rotary evaporation, add 300 mL of drinking water and extract with methylene chloride (150 mL × 3). Combine the organic phases. The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, concentrated,50.0 g red oily liquid. Yield 83.0%
References:
Weihai Disu Pharmaceutical Co., Ltd.;Disha Pharmaceutical Group Co., Ltd.;Pan Zhaoxi;Zhang Da;Gao Yongchen;Zhang Mingming CN107382963, 2017, A Location in patent:Paragraph 0013; 0017; 0021
![2-(ACETOXYMETHYL)-4-METHOXY-3,5-DIMETHYLPYRIDINE](/CAS/GIF/91219-90-8.gif)
91219-90-8
71 suppliers
inquiry
![3,5-Dimethyl-4-methoxy-2-pyridinemethanol](/CAS/GIF/86604-78-6.gif)
86604-78-6
294 suppliers
$7.00/5g
![2-HYDROXYMETHYL-3,5-DIMETHYL -4-CHLORO PYRIDINE](/CAS/GIF/150054-50-5.gif)
150054-50-5
45 suppliers
$54.00/100mg
![3,5-Dimethyl-4-methoxy-2-pyridinemethanol](/CAS/GIF/86604-78-6.gif)
86604-78-6
294 suppliers
$7.00/5g
![4-Methoxy-2,3,5-trimethylpyride-N-oxide](/CAS/GIF/86604-80-0.gif)
86604-80-0
92 suppliers
inquiry
![3,5-Dimethyl-4-methoxy-2-pyridinemethanol](/CAS/GIF/86604-78-6.gif)
86604-78-6
294 suppliers
$7.00/5g
![Methyl 4-Methoxy-3,5-diMethylpicolinate](/CAS/20150408/GIF/187222-18-0.gif)
187222-18-0
30 suppliers
inquiry
![3,5-Dimethyl-4-methoxy-2-pyridinemethanol](/CAS/GIF/86604-78-6.gif)
86604-78-6
294 suppliers
$7.00/5g