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ChemicalBook CAS DataBase List 3,5-DIMETHYL-FURAN-2-CARBOXYLIC ACID
34297-68-2

3,5-DIMETHYL-FURAN-2-CARBOXYLIC ACID synthesis

5synthesis methods
-

Yield:34297-68-2 69%

Reaction Conditions:

Stage #1: 3-methylfuran-2-carboxylic acidwith lithium diisopropyl amide in tetrahydrofuran at -78; for 0.25 h;
Stage #2: methyl iodide in tetrahydrofuran at -78 - 20;

References:

Crowley, Vincent M.;Khandelwal, Anuj;Mishra, Sanket;Stothert, Andrew R.;Huard, Dustin J. E.;Zhao, Jinbo;Muth, Aaron;Duerfeldt, Adam S.;Kizziah, James L.;Lieberman, Raquel L.;Dickey, Chad A.;Blagg, Brian S. J. [Journal of Medicinal Chemistry,2016,vol. 59,# 7,p. 3471 - 3488]