3-(ALLYLOXY)PIPERIDINE synthesis
- Product Name:3-(ALLYLOXY)PIPERIDINE
- CAS Number:946758-97-0
- Molecular formula:C8H15NO
- Molecular Weight:141.21
1026200-36-1
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Yield:-
Reaction Conditions:
with hydrogenchloride in ethyl acetate at 20; for 3 h;Cooling with ice;Inert atmosphere;
Steps:
2 (3R)(3S)-3-(Allyloxy)piperidine (3)
A 500mL round-bottom flask was charged with tert-butyl (3R)(3S)-3-(allyloxy)piperidine-1-carboxylate (9.60g, 39.8 mmol) and EtOAc (150 ml) then cooled in an ice bath under nitrogen.
The reaction solution was saturated with HCl (g) and stirred 1 h with cooling, then 2 h at RT.
Evaporation under reduced pressure gave a white solid, which was triturated with Et2O and isolated.
The solid was poured into 10M NaOH(aq) and extracted three times with DCM, dried with anhydrous MgSO4, filtered and rotary evaporated to give the title compound as a colorless oil.
References:
EP2268285,2018,B1 Location in patent:Paragraph 0100; 0101
1185297-03-3
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85275-45-2
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