ChemicalBook CAS DataBase List 1-Boc-3-hydroxypiperidine

1-Boc-3-hydroxypiperidine synthesis

8synthesis methods

Product Name:1-Boc-3-hydroxypiperidine
CAS Number:85275-45-2
Molecular formula:C10H19NO3
Molecular Weight:201.26

6859-99-0 Synthesis

6859-99-0
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$6.00/5g

24424-99-5 Synthesis

24424-99-5
824 suppliers
$13.50/25G

85275-45-2
368 suppliers
$7.00/5g

Yield:85275-45-2 99%

Reaction Conditions:

with triethylamine in methanol at 20; for 15 h;

Steps:

34.1 1)
1) 3-Hydroxypiperidine-1-carboxylic acid tert-butyl ester Triethylamine (15.2 mL) and a solution of di-tert-butoxydicarbonate (11.9 g) in methanol (50 mL) were added to a solution of 3-hydroxypiperidine (5.00 g) in methanol (50 mL) at room temperature, and the mixture was stirred for 15 hours. The solvent of the reaction mixture was evaporated under reduced pressure, and the residue was purified through silica gel column chromatography (ethyl acetate - chloroform), to thereby give 3-hydroxypiperidine-1-carboxylic acid tert-butyl ester as a solid product (9.86 g, 99%). ¹H-NMR(400MHz,CDCl₃)δ:1.36-1.55(2H,m), 1.45(9H,s), 1.71-1.78(1H,m), 1.88(1H,m), 3.02-3.13(2H,m), 3.52(1H,m), 3.72-3.76(2H,m). EI-MS m/z:201 (M⁺).

References:

DAIICHI PHARMACEUTICAL CO., LTD. EP1762568, 2007, A1 Location in patent:Page/Page column 49-50

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24424-99-5 Synthesis

24424-99-5
824 suppliers
$13.50/25G