3-Amino-2,6-dibromo-5-ethoxypyridine synthesis

Yield: 70%

Reaction Conditions:

with N-Bromosuccinimide in acetic acid at 20; for 0.5 h;

References:

Haydon, David J.;Bennett, James M.;Brown, David;Collins, Ian;Galbraith, Greta;Lancett, Paul;MacDonald, Rebecca;Stokes, Neil R.;Chauhan, Pramod K.;Sutariya, Jignesh K.;Nayal, Narendra;Srivastava, Anil;Beanland, Joy;Hall, Robin;Henstock, Vincent;Noula, Caterina;Rockley, Chris;Czaplewski, Lloyd [Journal of Medicinal Chemistry,2010,vol. 53,# 10,p. 3927 - 3936] Location in patent:supporting information; experimental part