3-Amino-6-cyanopyridine synthesis
- Product Name:3-Amino-6-cyanopyridine
- CAS Number:55338-73-3
- Molecular formula:C6H5N3
- Molecular Weight:119.12
100367-55-3
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55338-73-3
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$26.00/100mg
Yield:55338-73-3 91.3%
Reaction Conditions:
with carbamic Acid;palladium 10% on activated carbon in methanol for 16 h;Reflux;
Steps:
1.2 Step 2: Preparation of 5-aminopyridine-2-carbonitrile
To a solution of 5-nitropyridine-2-carbonitrile (7.0 g, 46.9 mmol) in methanol (150 mL) was added 10% palladium on carbon (2.0 g) and carbamic acid (7.0 g, 115 mmol). After being heated under reflux for 16 hours, the resulting mixture was filtered and the filtrate was concentrated in vacuo. The residue was dissolved in water (150 mL) and the resulting mixture was extracted with ethyl acetate (150 mL x 3). The organic layer was dried over sodium sulfate and concentrated in vacuo to afford 5.1 g of 5-aminopyridine-2-carbonitrile (yield was 9 1.3%).
References:
F. HOFFMANN-LA ROCHE AG;HOFFMANN-LA ROCHE INC.;WANG, Lisha;YUN, Hongying;ZHANG, Weixing;ZHENG, Xiufang WO2015/22301, 2015, A1 Location in patent:Page/Page column 28
4487-59-6
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55338-73-3
195 suppliers
$26.00/100mg
5418-51-9
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$12.72/1gm:
55338-73-3
195 suppliers
$26.00/100mg