3-AZABICYCLO[3.1.0]HEXAN-6-YLMETHANOL HCL synthesis

7synthesis methods

Product Name:3-AZABICYCLO[3.1.0]HEXAN-6-YLMETHANOL HCL
CAS Number:850808-44-5
Molecular formula:C6H12ClNO
Molecular Weight:149.62

3-AZABICYCLO[3.1.0]HEXAN-6-YLMETHANOL HCL

850808-44-5
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24424-99-5 Synthesis

24424-99-5
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$13.50/25G

850808-43-4 Synthesis

Tert-Butyl 6-(Hydroxymethyl)-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate

850808-43-4
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$55.00/25mg

Yield:-

Reaction Conditions:

with triethylamine in dichloromethane at 20; for 18 h;

Steps:

1

To a solution of (3-Aza-bicyclo[3.1.0]hex-6-yl)-methanol-HCl (11.8 gm, 78.7 mmol) in 350 mL of anhydrous CH₂Cl₂at room temperature was added Et₃N (32.9 mL, 236 mmol), followed by (BOC)₂O (18.9 gm, 86.6 mmol) in portions. The reaction was stirred at room temperature for 18 hours. The mixture was washed with saturated NaHCO₃, water, brine and dried over anhydrous MgSO₄. The mixture was filtered and concentrated under reduced pressure to yield the crude material, which was purified via flash chromatography with 10% MeOH/CH₂Cl₂. The product containing fractions were collected and concentrated to yield 6-Hydroxymethyl-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester (15.6 gm). 400 MHz ¹H NMR (CDCl₃) δ 3.4-3.6 (m, 4H), 3.2-3.7 (m, 2H), 1.72 (brs, 1H), 1.4-1.4 (m, 10H), 0.9-0.9 (m, 1H); MS (M+1) 213.2.

References:

US2006/229455,2006,A1 Location in patent:Page/Page column 11

850808-44-5
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912468-67-8 Synthesis

TERT-BUTYL 6-FORMYL-3-AZABICYCLO[3.1.0]HEXANE-3-CARBOXYLATE

912468-67-8
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References

850808-44-5
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3-Azabicyclo[3.1.0]hexane-3-carboxylic acid, 6-[[[3-fluoro-4-(4-morpholinyl)phenyl]amino]methyl]-, 1,1-dimethylethyl ester

850808-45-6
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References

850808-44-5
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3-Azabicyclo[3.1.0]hexane-3-carboxylic acid, 6-[[[3-fluoro-4-(4-morpholinyl)phenyl](2-thienylcarbonyl)amino]methyl]-, 1,1-dimethylethyl ester

850808-46-7
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References

850808-44-5
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2-Thiophenecarboxamide, N-[[3-(4-ethylbenzoyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]-N-[3-fluoro-4-(4-morpholinyl)phenyl]-

850808-51-4
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References