3-(benzyloxy)-4-methoxyaniline synthesis

8synthesis methods

Product Name:3-(benzyloxy)-4-methoxyaniline
CAS Number:61324-40-1
Molecular formula:C14H15NO2
Molecular Weight:229.27

75167-86-1
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61324-40-1
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Yield:61324-40-1 97.9%

Reaction Conditions:

with iron;ammonium chloride in ethanol;water at 85; for 1.5 h;

Steps:

1 Preparation of 3-benzyloxy-4-methoxyaniline

3-Benzyloxy-4-methoxynitrobenzene (10.0 g, 38.6 mmol), ammonium chloride (6.2 g, 115.8 mmol), iron powder (9.95 g, 177.6 mmol) were added successively to a 250 ml three- And ethanol-water (V: V = 2: 1) 120 ml. 85 °C was stirred and refluxed for 1.5 hours. The reaction was complete by thin layer chromatography (ethyl acetate: petroleum ether (V: V) = 1: 2), followed by hot suction. Add 80 ml of boiling water to the filtrate, then let cool to room temperature, dried to give 8.65 g of a dark red powdery solid in a yield of 97.9%.

References:

CN106946774,2017,A Location in patent:Paragraph 0049; 0050; 0054; 0055

636-93-1 Synthesis