3-Boc-aminomethylpyrrolidine synthesis
- Product Name:3-Boc-aminomethylpyrrolidine
- CAS Number:149366-79-0
- Molecular formula:C10H20N2O2
- Molecular Weight:200.28
172477-98-4
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149366-79-0
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$20.00/100mg
Yield:149366-79-0 90%
Reaction Conditions:
with hydrogen;palladium hydroxide on carbon in ethyl acetate at 20; for 3 h;
Steps:
10.A
Example 10; Preparation of N-METHYL-6- {[2-({3-[(methylamino)methyl]pyrrolidin-1-yl}carbonylthieno[3, 2- b] byridin-7-yl]oxy}-1-naphthamide; A. Preparation of Intermediate 10a:; tert-Butyl pyrrolidin-3-ylmethylcarbamate To a solution of tert-butyl (1-benzylpyrrolidin-3-yl) methylcarbamate (3. 0g, 10.33 MMOL) in EtOAc (100 mL) was added Pd (OH) z on carbon (0.3 G). The mixture was stirred under H2 balloon at room temperature for 3 h and filtered through Celite. The filtrate was concentrated to give colorless oil (1.87 g, 90%) and used as it is for the next step
References:
PFIZER INC. WO2005/21553, 2005, A1 Location in patent:Page/Page column 54-55
155497-10-2
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149366-79-0
129 suppliers
$20.00/100mg