ChemicalBook CAS DataBase List 4-BOC-AMINOMETHYL-3-HYDROXY-1-N-BOC-PYRROLIDINE

4-BOC-AMINOMETHYL-3-HYDROXY-1-N-BOC-PYRROLIDINE synthesis

7synthesis methods

Product Name:4-BOC-AMINOMETHYL-3-HYDROXY-1-N-BOC-PYRROLIDINE
CAS Number:175463-34-0
Molecular formula:C15H28N2O5
Molecular Weight:316.39

24424-99-5 Synthesis

24424-99-5
822 suppliers
$13.50/25G

175463-32-8 Synthesis

175463-32-8
243 suppliers
$6.00/1g

4-BOC-AMINOMETHYL-3-HYDROXY-1-N-BOC-PYRROLIDINE

175463-34-0
31 suppliers
$284.00/1g

Yield:175463-34-0 80.6%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol at 50; under 30003 Torr; for 18 h;Autoclave;

Steps:

1 Synthesis of 2.4- (N-tert-Butoxycarbonyl) aminomethyl-1- (N-t-butoxycarbonyl) pyrrolidin-3-ol (4)

316.5 g (78.6 mmol) of the compound, 2 g of 10% wet palladium carbon, 17 g (78.6 mmol) of di-t-butyl dicarbonateInto the autoclave, 200 mL of methanol was added, hydrogen was pressurized to 4 MPa, and the temperature was raised to 50 ° C, and the reaction was carried out for 18 hours.Palladium carbon was filtered off and the filtrate was dried to give 26 g of a pale yellow oil. The crude product was dissolved in 100 mL of petroleum ether: ethyl acetate = 5: 1Solvent, cooled to -4 ° C and filtered to give 20 g of a white solid. Yield: 80.6%.

References:

CN105585518,2016,A Location in patent:Paragraph 0027; 0028

44981-94-4 Synthesis