ChemicalBook CAS DataBase List 3-bromo-1,2-dimethyl-1H-indole

3-bromo-1,2-dimethyl-1H-indole synthesis

6synthesis methods

Product Name:3-bromo-1,2-dimethyl-1H-indole
CAS Number:80906-24-7
Molecular formula:C10H10BrN
Molecular Weight:224.1

1496-78-2 Synthesis

1496-78-2
25 suppliers
$45.00/25mg

74-88-4
342 suppliers
$15.00/10g

80906-24-7
18 suppliers
$175.00/100mg

Yield:80906-24-7 97%

Reaction Conditions:

Stage #1: 3-bromo-2-methyl-1H-indolewith sodium hydride in tetrahydrofuran at 20; for 0.666667 h;Inert atmosphere;
Stage #2: methyl iodide in tetrahydrofuran at 20; for 15 h;Inert atmosphere;

Steps:

1.2.2 (2) Synthesis of 1,2-dimethyl-3-bromoindole

3.5 mmol of 2-methyl-3-bromoindole was dissolved in 10 mL of THF under nitrogen, and stirred for 10 minutes.Add 5 mmol of NaH, stir at room temperature for 30 minutes, add 5 mmol of CH3I, and stir at room temperature for 15 hours.After the reaction was completed, 20 mL of water was added, and the mixture was extracted with diethyl ether for 3 times, then dried over anhydrous magnesium sulfate and evaporated.The product 1,2-dimethyl-3-bromoindole was obtained in a 97% yield.

References:

CN109721593,2019,A Location in patent:Paragraph 0043; 0052; 0056-0058