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3-broMo-2,4-diMethylthiophene synthesis

5synthesis methods
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Yield:79485-96-4 83%

Reaction Conditions:

Stage #1: 2,4-dibromo-3,5-dimethylthiophenewith n-butyllithium in tetrahydrofuran;hexane at -78;
Stage #2: in tetrahydrofuran;methanol;hexane at -78 - 20;Further stages.;

References:

De Meijere, Armin;Ligang, Zhao;Belov, Vladimir N.;Bossi, Mariano;Noltemeyer, Matthias;Hell, Stefan W. [Chemistry - A European Journal,2007,vol. 13,# 9,p. 2503 - 2516]