![](/CAS/GIF/55758-02-6.gif)
3-Bromo-2-cyanopyridine synthesis
- Product Name:3-Bromo-2-cyanopyridine
- CAS Number:55758-02-6
- Molecular formula:C6H3BrN2
- Molecular Weight:183.01
![3-BROMOPYRIDINE-N-OXIDE](/CAS/GIF/2402-97-3.gif)
2402-97-3
120 suppliers
$30.00/1 g
![Trimethylsilyl cyanide](/CAS/GIF/7677-24-9.gif)
7677-24-9
373 suppliers
$19.00/5g
![3-Bromo-2-cyanopyridine](/CAS/GIF/55758-02-6.gif)
55758-02-6
258 suppliers
$6.00/1g
Yield:55758-02-6 89%
Reaction Conditions:
with triethylamine in acetonitrile at 75; for 15 h;Inert atmosphere;
Steps:
1.1; 2.1; 3.1; 4.1; 5.1; 6.1
Dissolve 3-bromopyridine-N-oxide (19.2g, 110.4mmol, 1eq.) in 280ml acetonitrile, under the protection of nitrogen,Trimethylsilyl cyanide (32.9g, 331.2mmol, 3eq.) and triethylamine (22.3g, 220.8mmol, 2eq.) were sequentially added, and reacted at 75°C for 15 hours.After the reaction is over, after the reaction liquid is cooled, the reaction liquid is added to a saturated sodium bicarbonate solution in ice.Extract with ethyl acetate, wash the organic phase with saturated sodium chloride, and then dry,Purified by column chromatography to obtain 18 g of white solid 3-bromo-2-cyanopyridine with a yield of 89%.
References:
Ali Biological New Materials (Changzhou) Co., Ltd.;Shi Jianyun;Liu Chao;Dai Hongsheng;Gu Yunlong;Jiang Yunqing CN111285798, 2020, A Location in patent:Paragraph 0028-0029; 0032-0033; 0066-0067; 0070-0071
![3-Pyridyl bromide](/CAS/GIF/626-55-1.gif)
626-55-1
536 suppliers
$5.00/5 / G
![POTASSIUM CYANIDE](/CAS/GIF/151-50-8.gif)
151-50-8
4 suppliers
$36.39/100g
![3-Bromo-2-cyanopyridine](/CAS/GIF/55758-02-6.gif)
55758-02-6
258 suppliers
$6.00/1g
![3-BROMOPYRIDINE-N-OXIDE](/CAS/GIF/2402-97-3.gif)
2402-97-3
120 suppliers
$30.00/1 g
![Trimethylsilyl cyanide](/CAS/GIF/7677-24-9.gif)
7677-24-9
373 suppliers
$19.00/5g
![5-Bromonicotinonitrile](/CAS/GIF/35590-37-5.gif)
35590-37-5
226 suppliers
$6.00/250mg
![3-Bromo-2-cyanopyridine](/CAS/GIF/55758-02-6.gif)
55758-02-6
258 suppliers
$6.00/1g
![3-Pyridyl bromide](/CAS/GIF/626-55-1.gif)
626-55-1
536 suppliers
$5.00/5 / G
![Trimethylsilyl cyanide](/CAS/GIF/7677-24-9.gif)
7677-24-9
373 suppliers
$19.00/5g
![3-Bromo-2-cyanopyridine](/CAS/GIF/55758-02-6.gif)
55758-02-6
258 suppliers
$6.00/1g
![3-Bromo-4-cyanopyridine](/CAS/GIF/13958-98-0.gif)
13958-98-0
163 suppliers
$10.00/100mg
![5-Bromo-2-pyridinecarbonitrile](/CAS/20180808/GIF/97483-77-7.gif)
97483-77-7
550 suppliers
$10.00/5g
![3-BROMOPYRIDINE-N-OXIDE](/CAS/GIF/2402-97-3.gif)
2402-97-3
120 suppliers
$30.00/1 g
![Trimethylsilyl cyanide](/CAS/GIF/7677-24-9.gif)
7677-24-9
373 suppliers
$19.00/5g
![3-Bromo-2-cyanopyridine](/CAS/GIF/55758-02-6.gif)
55758-02-6
258 suppliers
$6.00/1g
![5-Bromo-2-pyridinecarbonitrile](/CAS/20180808/GIF/97483-77-7.gif)
97483-77-7
550 suppliers
$10.00/5g