3-BROMO-4-CHLORO-2-CYANOPYRIDINE synthesis
- Product Name:3-BROMO-4-CHLORO-2-CYANOPYRIDINE
- CAS Number:1427158-10-8
- Molecular formula:C6H2BrClN2
- Molecular Weight:217.45
Yield:1427158-10-8 4 g
Reaction Conditions:
with triethylamine in acetonitrile at 80; for 5 h;
Steps:
1.2 Step 2: Preparation of 3-bromo-4-chloropyridine-2-carbonitrile
To a solution of 3-bromo-4-chloropyridine 1-oxide (7 g, 33.58 mmol) in CH3CN was added trimethylsilyl cyanide (13.35 g, 134.6 mmol) and Ε?3 (15.61 g, 117 mmol) and the reaction mixture was heated at 80 °C for 5 h. The reaction was quenched with water and was extracted with ethyl acetate. The organic layer was separated, dried, filtered and concentrated. The concentrate was purified by column chromatography to afford 4 g of the title product. H NMR (300 MHz, CDC13): δ 8.54 (d, /= 4.8 Hz, 1H), 7.63 (d, J = 5.4 Hz, 1H).
References:
WO2013/38308,2013,A1 Location in patent:Page/Page column 36
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