![](/CAS/GIF/40180-80-1.gif)
3'-BROMO-4'-METHYLACETOPHENONE synthesis
- Product Name:3'-BROMO-4'-METHYLACETOPHENONE
- CAS Number:40180-80-1
- Molecular formula:C9H9BrO
- Molecular Weight:213.07
![4'-Methylacetophenone](/CAS/GIF/122-00-9.gif)
122-00-9
680 suppliers
$5.00/25g
![3'-BROMO-4'-METHYLACETOPHENONE](/CAS/GIF/40180-80-1.gif)
40180-80-1
183 suppliers
$23.00/1g
Yield:40180-80-1 93%
Reaction Conditions:
Stage #1:para-methylacetophenone with aluminum (III) chloride in dichloromethane at 0; for 0.666667 h;Inert atmosphere;Schlenk technique;Glovebox;
Stage #2: with bromine in dichloromethane at 20; for 1 h;Inert atmosphere;Schlenk technique;Glovebox;
Steps:
3-Bromo-4-methylacetophenone
A solution of 97 g (723 mol) of 4-methylacetophenone in 100 ml of dichloromethane was added by vigorous stirring over 30 min to a suspension of 237 g (1.78 mol) of AlCl3 in 700 ml of dichloromethane at 0 °C. The reaction mixture was then stirred for 10 min at this temperature, then 40.0 ml (125 g, 0.781 mol, 8% excess) of bromine was added dropwise over 1 h. The resulting mixture was stirred overnight at room temperature and then poured onto 2000 cm3 of ice. The organic layer was separated, and the aqueous layer was extracted with 3 x 150 ml ofdichloromethane. The combined organic extract was washed with aqueous K2CO3, dried over K2CO3, passed through a short pad of silica gel 60 (40-63 μιη), and then evaporated to dryness. Crude product was distilled under vacuum to give 143 g (93%) of a colorless liquid (b.p. 125-132 °C/8 mm Hg) which completely solidified on standing at room temperature.
References:
BOREALIS AG;RESCONI, Luigi;VIRKKUNEN, Ville;NOUREDDINE, Ajellal;CASTRO, Pascal;IZMER, Vyatcheslav;KONONOVICH, Dmitry;VOSKOBOYNIKOV, Alexander WO2014/96282, 2014, A1 Location in patent:Page/Page column 44; 45
![1-(4-Methylphenyl)ethanol](/CAS/GIF/536-50-5.gif)
536-50-5
105 suppliers
$29.00/1g
![3'-BROMO-4'-METHYLACETOPHENONE](/CAS/GIF/40180-80-1.gif)
40180-80-1
183 suppliers
$23.00/1g
![4'-Methylacetophenone](/CAS/GIF/122-00-9.gif)
122-00-9
680 suppliers
$5.00/25g
![1-(4-Methylphenyl)ethanol](/CAS/GIF/536-50-5.gif)
536-50-5
105 suppliers
$29.00/1g
![3'-BROMO-4'-METHYLACETOPHENONE](/CAS/GIF/40180-80-1.gif)
40180-80-1
183 suppliers
$23.00/1g
![Benzenemethanol, 3-bromo-α,4-dimethyl-](/CAS/20211123/GIF/65189-93-7.gif)
65189-93-7
3 suppliers
inquiry
![4'-Methylacetophenone](/CAS/GIF/122-00-9.gif)
122-00-9
680 suppliers
$5.00/25g
![2-Bromo-4'-methylacetophenone](/CAS/GIF/619-41-0.gif)
619-41-0
244 suppliers
$6.00/1g
![1-(4-Methylphenyl)ethanol](/CAS/GIF/536-50-5.gif)
536-50-5
105 suppliers
$29.00/1g
![3'-BROMO-4'-METHYLACETOPHENONE](/CAS/GIF/40180-80-1.gif)
40180-80-1
183 suppliers
$23.00/1g
![Benzenemethanol, α-(bromomethyl)-4-methyl-](/CAS/20211123/GIF/60655-81-4.gif)
60655-81-4
2 suppliers
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![4'-Methylacetophenone](/CAS/GIF/122-00-9.gif)
122-00-9
680 suppliers
$5.00/25g
![2-Bromo-4'-methylacetophenone](/CAS/GIF/619-41-0.gif)
619-41-0
244 suppliers
$6.00/1g
![1-(4-Methylphenyl)ethanol](/CAS/GIF/536-50-5.gif)
536-50-5
105 suppliers
$29.00/1g
![3'-BROMO-4'-METHYLACETOPHENONE](/CAS/GIF/40180-80-1.gif)
40180-80-1
183 suppliers
$23.00/1g
![Benzenemethanol, 3-bromo-α,4-dimethyl-](/CAS/20211123/GIF/65189-93-7.gif)
65189-93-7
3 suppliers
inquiry
![Benzenemethanol, α-(bromomethyl)-4-methyl-](/CAS/20211123/GIF/60655-81-4.gif)
60655-81-4
2 suppliers
inquiry
![4'-Methylacetophenone](/CAS/GIF/122-00-9.gif)
122-00-9
680 suppliers
$5.00/25g
![2-Bromo-4'-methylacetophenone](/CAS/GIF/619-41-0.gif)
619-41-0
244 suppliers
$6.00/1g