ChemicalBook CAS DataBase List 3-BROMO-4-PHENYLPYRIDINE

3-BROMO-4-PHENYLPYRIDINE synthesis

6synthesis methods

Product Name:3-BROMO-4-PHENYLPYRIDINE
CAS Number:88345-89-5
Molecular formula:C11H8BrN
Molecular Weight:234.09

89167-19-1
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98-80-6 Synthesis

98-80-6
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88345-89-5
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$60.00/250mg

Yield:88345-89-5 65%

Reaction Conditions:

with tetrakis(triphenylphosphine) palladium⁽⁰⁾;potassium carbonate in ethanol;toluene; for 24 h;Reflux;

Steps:

3

After dissolving 135.78g (478.27mmol) of Intermediate 72-1 and 69.98g (573.92mmol) of Intermediate 72-2 in 1.4L of toluene, 2M K2CO3717ml (1434.81mmol), EtOH 140ml, Pd(PPh3) 427.63g (23.91mmol) were added. And refluxed for 24 hours and stirred. After confirming the completion of the reaction, the water layer was removed and the solvent was distilled off. After the column, 72.77 g of the intermediate 72-3 was obtained in a yield of 65%.

References:

KR2020/108163,2020,A Location in patent:Paragraph 0230-0234