ChemicalBook CAS DataBase List 3-Bromo-N-methyl-5-nitrobenzamide

3-Bromo-N-methyl-5-nitrobenzamide synthesis

6synthesis methods

Product Name:3-Bromo-N-methyl-5-nitrobenzamide
CAS Number:90050-52-5
Molecular formula:C8H7BrN2O3
Molecular Weight:259.06

6307-87-5 Synthesis

6307-87-5
115 suppliers
$9.00/1g

74-89-5 Synthesis

74-89-5
7 suppliers
$13.44/25ML

90050-52-5
30 suppliers
$45.00/100mg

Yield:90050-52-5 94.6%

Reaction Conditions:

with 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran;methanol at 20;Reagent/catalyst;Solvent;

Steps:

3 (S3) Preparation of N-methyl-3-bromo-5-nitrobenzamide (formula V.).

Methyl 3-bromo-5-nitrobenzoate (formula IV.) 26g was added to a 250mL three-mouth flask, tetrahydrofuran 60mL, 1,8-diazabicyclo [5.4.0] undecyl-7-alkene 3mL, stirred and dissolved at room temperature; Slowly add 12mol/L of methanamine methanol solution 60 mL; Drip, room temperature stirring overnight, after the end of the reaction, the reaction solution is concentrated, add 1mol / L aqueous hydrochloric acid solution 100mL beating, filtering, filter cake drying, to give a yellow solid compound N- methyl-3-bromo-5-nitrobenzamide 24.5g, purity of 99.2%, yield of 94.6%.

References:

CN114716340,2022,A Location in patent:Paragraph 0069-0075

6307-83-1 Synthesis