3-bromo-Thieno[2,3-d]pyridazin-4(5H)-one synthesis
- Product Name:3-bromo-Thieno[2,3-d]pyridazin-4(5H)-one
- CAS Number:1433203-93-0
- Molecular formula:C6H3BrN2OS
- Molecular Weight:231.07
1433203-92-9
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Yield:1433203-93-0 59%
Reaction Conditions:
with hydrazine in tetrahydrofuran;ethanol at 80; for 2 h;
Steps:
335.3 Ste 3: (0642) Preparation of 3-bromothieno[2,3-d]pyridazin-4(5H)-one
Ste 3: (0642) Preparation of 3-bromothieno[2,3-d]pyridazin-4(5H)-one: (0643) [00260] To a solution of ethyl 4-bromo-2-formylthiophene-3-carboxylate (1.56 g, 5.93 mmol) in ethanol (10 mL) was added hydrazine solution (1M in tetrahydofuran solution). The reaction mixture was heated to 80 °C and stirred for 2h. The mixture was allowed to cool to room temperature, the precipitated product was filtered, washed with dichloromethane and dried to obtain title compound 3-bromothieno[2,3-d]pyridazin-4(5H)-one (0.81 g, 59% yield) as a white solid. Calculated (M+H): 230.91; Found (M+H): 230.9
References:
WO2017/100591,2017,A1 Location in patent:Paragraph 00260
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