3-Bromomethyl-6-trifluoromethyl-pyridazine synthesis
- Product Name:3-Bromomethyl-6-trifluoromethyl-pyridazine
- CAS Number:1173897-85-2
- Molecular formula:C6H4BrF3N2
- Molecular Weight:241.01
1173897-84-1
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1173897-85-2
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Yield:1173897-85-2 28%
Reaction Conditions:
with N-Bromosuccinimide;2,2'-azobis(isobutyronitrile) in tetrachloromethane at 80;
Steps:
166-167.2 Step 2:
A solution of 3-methyl-6-(trifluoromethyl)pyridazine (400 mg, 2.47 mmol) and NBS (483 mg, 2.71 mmol) in CC14(8 mL) was treated with 2,2'-azobis(2- methylpropionitrile) (81 mg, 0.493 mmol), stirred at 8o°C for 16 hours and concentrated under reduced pressure. The residue was purified by flash chromatography (ISCO; 12 g SepaFlash, 0-18% EtOAc in petroleum ether) to afford 3-(bromomethyl)-6-(trifluoromethyl)pyridazine (168 mg, 28%) as a red oil.
References:
WO2022/167819,2022,A1 Location in patent:Page/Page column 182
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1173897-85-2
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