3-Chloro-6-trifluoromethyl-pyridazine synthesis
- Product Name:3-Chloro-6-trifluoromethyl-pyridazine
- CAS Number:258506-68-2
- Molecular formula:C5H2ClF3N2
- Molecular Weight:182.53
174607-36-4
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$35.00/100mg
258506-68-2
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$22.00/250mg
Yield:258506-68-2 92%
Reaction Conditions:
with thionyl chloride;N,N-dimethyl-formamide for 2 h;Heating / reflux;
Steps:
Reference Example 313
Reference Example 313 A mixture of6- (trifluoromethyl)-3-pyridazinone (1.41 g), thionyl chloride (1.5 ml) and N, N-dimethylformamide (0.3 ml) was refluxed for 2 hours. Excess thionyl chloride was evaporated under reduced pressure and aqueous sodium hydrogen carbonate was added. The mixture was extracted with diethyl ether. The diethyl ether layer was washed with saturated brine, dried(MgS04) and concentrated. The residue was subjected to silica gel column chromatography, and 3-chloro-6- (trifluoromethyl) pyridazine (1.45 g, yield92%) was obtained as white crystals from a fraction eluted with ethyl acetate- hexane (1: 3, volume ratio). melting point:51-52 C.lH-NMR (CDC13) 6 : 7.75(1H, dd, J=8.7, 0.6 Hz), 7.82(1H, d, J=9.0Hz).
References:
WO2003/99793,2003,A1 Location in patent:Page 272
1514-87-0
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135034-10-5
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$9.00/250mg
258506-68-2
186 suppliers
$22.00/250mg
81290-20-2
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$13.00/1g
135034-10-5
176 suppliers
$9.00/250mg
258506-68-2
186 suppliers
$22.00/250mg
174607-36-4
88 suppliers
$35.00/100mg
258506-68-2
186 suppliers
$22.00/250mg
628332-15-0
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258506-68-2
186 suppliers
$22.00/250mg