ChemicalBook CAS DataBase List 3-BUTOXY-4-METHOXYBENZOIC ACID

3-BUTOXY-4-METHOXYBENZOIC ACID synthesis

5synthesis methods

Product Name:3-BUTOXY-4-METHOXYBENZOIC ACID
CAS Number:66924-20-7
Molecular formula:C12H16O4
Molecular Weight:224.25

Benzoic acid, 3-butoxy-4-methoxy-, methyl ester

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66924-20-7
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Yield:66924-20-7 99%

Reaction Conditions:

with water;sodium hydroxide in ethanol at 60; for 1.5 h;

Steps:

13.2 Step 2: 3-Butoxy-4-methoxybenzoic acid

Step 2: 3-Butoxy-4-methoxybenzoic acid[0665]To a mixed sovent of ethanol (150 mL) and water (50 mL) were added methyl 3-butoxy-4-methoxybenzoate (12.89 g, 54.16 mmol) and sodium hydroxide (6.5 g, 162.48 mmol) . The mixture was stirred at 60 for 1.5 hours and then concentrated to remove the ethanol. To the residue was added hydrochloric acid (1 M) to adjust the pH to 1. The resulting mixture was extracted with ethyl acetate (50 mL × 3) and the combined organic layers were dried over anhydrous sodium sulfate. The organic layers was concentrated to give the title compound as a white solid (12.02 g, 99) .

References:

WO2015/161830,2015,A1 Location in patent:Paragraph 00327