3-butyl-2-thioxothiazolidin-4-one synthesis

6synthesis methods

Product Name:3-butyl-2-thioxothiazolidin-4-one
CAS Number:21494-64-4
Molecular formula:C7H11NOS2
Molecular Weight:189.3

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109-73-9 Synthesis

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Yield:21494-64-4 94%

Reaction Conditions:

with triethylamine in acetonitrile at 20; for 0.166667 h;

Steps:

3.3. General Procedure B: Synthesis of 4a-4al

General procedure: A mixture of amine (0.5 mmol) or diamine (0.25 mmol), carbon disulfide (38 mg, 0.5 mmol),methyl (2-chloroacetyl)carbamate (76 mg, 0.5 mmol), and triethylamine (61 mg, 0.6 mmol) in MeCN(3 mL) was stirred at room temperature for 10 min. After disappearance of the reactant (monitoredby TLC), added 50 mL water to the mixture, then extracted with ethyl acetate 3 times (3 x 50 mL).The extract was dried over anhydrous Na2SO4 and evaporated. The residue was purified by columnchromatography on silica gel to give 4a-4al.

References:

Huo, Zhipeng;Liang, Yongxi;Sun, Xun;Tang, Mei-Lin;Zhang, Chenchen [Molecules,2020,vol. 25,# 5]

75-15-0
247 suppliers
$40.00/100g

109-73-9 Synthesis

109-73-9
447 suppliers
$9.00/1g